Event Details

Friday, 10 March 2017
11:00 am - 12:00 pm
QBI Level 7 Auditorium
UQ Location:
Queensland Brain Institute (St Lucia)
Event category(s):

Event Contact

Ms Deirdre Wilson
334 66300
Org. Unit:
Queensland Brain Institute

Event Description

Full Description:
A/Professor Zhiyi Wei
Department of Biology, Southern University of Science and Technology (SUSTech)
Guangdong Sheng, China

Title: Structural Insights into Presynaptic Active Zone Assembly
Abstract: Neurotransmitter release relies on an highly specialized presynaptic terminal region, called the active zone. The active zone contains a large number of proteins, including adhesion molecules, receptors, adaptors and scaffolds, which are assembled to form the electron-dense material. How the active zone is assembled properly to fulfill its function and how the assembly is regulated remain elusive. Liprin-alpha, a synaptic scaffold, was found to play a critical role in active zone assembly, by recruiting numerous synaptic proteins. To understand the assembly mechanism of the active zone, we characterized liprin-alpha by combining structural biology, biochemistry and cell biology. Here, I will present our findings.

Directions to UQ

Google Map:
To St Lucia Campus, UQ Ipswich, and UQ Gatton.

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