CAI Seminar Series: Fluorine-18 for Labeling Small Molecules to Large Molecules for In Vivo PET Imaging

Event Details

Date:

Tuesday, 12 March 2019

Time:

9:30 am - 10:30 am

Room:

Level 2 seminar room

Location:

Building 57, Centre for Advanced Imaging, St Lucia campus

URL:

https://cai.centre.uq.edu.au/event/session/1524

Event category(s):

Full Description:: Dr Muneer Ahamed, Postdoctoral Research Fellow (Thurecht Group),
Centre for Advanced Imaging and Centre for Innovation in Biomedical Imaging Technology (CIBIT)

The University of Queensland, presents:

Fluorine-18 for Labeling Small Molecules to Large Molecules for In Vivo PET Imaging

Fluorine-18 is the most frequently used radioisotope in positron emission tomography (PET) in both clinical and preclinical research. Its physical and nuclear characteristics (97% β+ decay, 109.7 min half-life, 635 keV positron energy), along with ease of large scale production (~370 GBq/batch) with high specific activity, make it an attractive nuclide for radiochemical labeling and molecular imaging. The first part of this lecture will deal with development of 18F-labeled small molecule for imaging brain cannabinoid 2 receptor (CB2R), with emphasis to imaging neuroinflammation. The second part will discuss new methods for 18F-labeling of peptides and biomolecules.