Event Details

Thursday, 14 March 2019
12:00 pm - 1:00 pm
AIBN Level 1 Seminar Room
UQ Location:
Australian Institute for Bioengineering and Nanotechnology (St Lucia)
Event category(s):

Event Contact

Mrs Anne-Marie Paroz
3346 3877
Org. Unit:
Australian Institute for Bioengineering and Nanotechnology

Event Description

Full Description:
Principles of mechanosensing at the membrane interface:

Efficient mechanotransduction processes occur in living organisms via mechanosensors or mechanoreceptors linking external mechanical stimuli at the cell surface to intracellular signaling events and downstream effectors. Mechanosensitive (MS) ion channels are among the fastest primary mechanosensors converting mechanical stimuli into intracellular signals on a submillisecond time scale.

Much of our understanding of the biophysical principles that underlie and direct conversion of mechanical force into conformational changes in MS channels comes from studies based on MS channel reconstitution into lipid bilayers. My talk will focus on close interactions between MS channels and the lipid bilayer and discuss the central role that transbilayer pressure profile plays in mechanosensitivity and gating of these fascinating membrane proteins.

Directions to UQ

Google Map:
To St Lucia Campus, UQ Ipswich, and UQ Gatton.

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