Event Details

Friday, 25 August 2017
12:30 pm - 1:30 pm
Queensland Bioscience Precinct Auditorium - Building 80, The University of Queensland
UQ Location:
Queensland Bioscience Precinct (St Lucia)
Event category(s):

Event Contact

Ms Katrina Garner-Moore
3346 2110
Org. Unit:
Institute for Molecular Bioscience

Event Description

Full Description:
“Genetic variants within complement factor H (CFH) and the five complement factor H-related (CFHR) genes have been associated with susceptibility to a range of human diseases. Factor H (FH) acts as a negative regulator of the alternative complement activation pathway and its circulating plasma levels, mainly secreted by the liver, have been associated with susceptibility to infectious and autoimmune diseases. We have characterized the extremely complex CFH-CFHR1-5 gene interval and fine-mapped the association signal of susceptibility to meningococcal disease. Functional studies demonstrated that the lead SNP in CFHR3 lies in a liver-specific regulatory region that has been shown to loop and interact with CFH at the genomic level. Our data demonstrate that FH is the complement protein associated with meningococcal disease susceptibility and that its expression levels are controlled through a cis-regulatory element located in intron 1 of CFHR3 providing a molecular mechanism relevant to complement dysregulation related diseases”

Directions to UQ

Google Map:
To St Lucia Campus, UQ Ipswich, and UQ Gatton.

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