Event Details

Friday, 12 May 2017
12:30 pm - 1:30 pm
Queensland Bioscience Precinct Auditorium - Building 80, The University of Queensland
UQ Location:
Queensland Bioscience Precinct (St Lucia)
Event category(s):

Event Contact

Ms Katrina Garner-Moore
3346 2110
Org. Unit:
Institute for Molecular Bioscience

Event Description

Full Description:
The immune activation of macrophages via Toll-like receptors (TLR) triggers powerful pro-inflammatory cytokine responses, followed by inflammation-resolving, anti-inflammatory responses. An imbalance in this programming accompanies and contributes to acute and chronic inflammation in disease. Complex networks of regulators modulate TLR-induced signalling pathways and transcriptional programs to bias cytokine production. Our research has uncovered novel roles for Rab GTPases, signalling adaptors, phospholipid kinases and cross-talk receptors that participate in biasing macrophage outputs and functions. TLR signalling is also spatiotemporally controlled, and using advanced live cell imaging we can reveal the dynamic cell surface structures and compartments that host signalling regulators and traffic receptors. This research is piecing together a landscape of druggable targets for controlling inflammation.

Directions to UQ

Google Map:
To St Lucia Campus, UQ Ipswich, and UQ Gatton.

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