Event Details

Friday, 05 May 2017
12:30 pm - 1:30 pm
Queensland Bioscience Precinct Auditorium - Building 80, The University of Queensland
UQ Location:
Queensland Bioscience Precinct (St Lucia)
Event category(s):

Event Contact

Ms Katrina Garner-Moore
3346 2110
Org. Unit:
Institute for Molecular Bioscience

Event Description

Full Description:
Mutation leading to constitutive -catenin activity are present in nearly all colon cancers and are essential for maintaining tumour growth. However, despite large efforts we lack efficient -catenin inhibitors. We have taken an alternative approach, using genome wide RNAi and CRISPR screens to identify genes that are required for proliferation only in the context of aberrant -catenin activity. We demonstrate the utility and off target effects of each of these approaches and describe a new platform that combines different methodologies and enables identification of highly specific cell essential genes. Our work identified a transcriptional complex composed of -catenin and YAP1 that drives the expression of genes that promote cancer cell survival. Although my work is focused on -catenin driven colon cancer the same approaches could be applied as a general strategy for unbiased studies of how genes function in normal tissues and how they are deregulated in disease.

Directions to UQ

Google Map:
To St Lucia Campus, UQ Ipswich, and UQ Gatton.

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