IMB Seminar Series - Professor John F. Hancock - K- Ras membrane anchoring: new twists in an old tale

Event Details

Date:

Friday, 28 April 2017

Time:

12:30 pm - 1:30 pm

Room:

Queensland Bioscience Precinct Auditorium - Building 80, The University of Queensland

UQ Location:

Queensland Bioscience Precinct (St Lucia)

URL:

http://events.imb.uq.edu.au/seminar.php?id=1124

Event category(s):

Full Description:: Ras proteins are small, membrane-localized GTPases that regulate cell proliferation and differentiation. Three highly homologous Ras isoforms, H-, N- and K-Ras are ubiquitously expressed in mammalian cells and are present in mutated activated state in 15% of all human tumors. Ras must localize to the plasma membrane in order to function. Our recent work has examined how different Ras proteins select and sort highly specific phospholipids into plasma membrane signaling platforms, how these transient lipid assemblies impact signal transmission and in consequence how the lipid composition of the plasma membrane can operate as high-level regulator of Ras signal transmission. These recent observations suggest new approaches to inhibit oncogenic Ras signaling that are the basis of our translational program for anti K-Ras drugs.