IMB Seminar Series - Associate Professor Colin Jackson - 'Predicting the future and reconstructing the past through protein engineering'
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- In this talk I will discuss some recent results from our laboratory in which we have used a variety of protein engineering approaches (loop design, ancestral reconstruction, directed evolution, combinatorial mutagenesis) to answer questions such as: How will TB evolve resistance to next-gen antibiotics? How will pesticide resistance develop? How can enzymes evolve novel functions? And how can enzymatic activity emerge from a non-catalytic binding protein scaffold?
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