IMB Seminar Series - Associate Professor Kathyrn Holt - 'Genomic insights into evolution and dissemination of antimicrobial resistance'
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- 'Genomic insights into evolution and dissemination of antimicrobial resistance'
High throughput DNA sequencing has revolutionised our ability to investigate and understand bacterial pathogen populations. I have been involved in establishing and applying population genomic frameworks and associated tools to the study of several important pathogens, including typhoid, dysentery and the emerging hospital superbugs Klebsiella pneumoniae and Acinetobacter baumannii. The insights and implications offered by population genomics vary substantially between organisms, but understanding the evolution and spread of antimicrobial resistance is a common and important goal. Here I will highlight some recent insights into the evolution and spread of two highly drug-resistant bacterial pathogens that have very different population structures – Salmonella Typhi (typhoid) and Klebsiella pneumoniae.
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