IMB Seminar Series - Associate Professor Joseph (Sefi) Rosenbluh
Event Details
Event Contact
Event Description
- Full Description:
- Mutation leading to constitutive -catenin activity are present in nearly all colon cancers and are essential for maintaining tumour growth. However, despite large efforts we lack efficient -catenin inhibitors. We have taken an alternative approach, using genome wide RNAi and CRISPR screens to identify genes that are required for proliferation only in the context of aberrant -catenin activity. We demonstrate the utility and off target effects of each of these approaches and describe a new platform that combines different methodologies and enables identification of highly specific cell essential genes. Our work identified a transcriptional complex composed of -catenin and YAP1 that drives the expression of genes that promote cancer cell survival. Although my work is focused on -catenin driven colon cancer the same approaches could be applied as a general strategy for unbiased studies of how genes function in normal tissues and how they are deregulated in disease.
Directions to UQ
Event Tools
Share This Event
Print
Email
Share
Rate This Event
Tweet This Event
Calendar Tools
Featured Calendars
Subscribe via RSS