Centre for Marine Science - Special Seminar Series - 23rd November @ 4 pm
Event Details
- Date:
- Tuesday, 23 November 2021 - Tuesday, 23 November 2021
- Time:
- 4:00 pm - 5:00 pm
- Location:
- https://uqz.zoom.us/meeting/register/tZcpduuuqTIsE9Qee-kSPYKQkUo4HgvVYYRo
- URL:
- https://marine.uq.edu.au/content/seminar-series
- Event category(s):
Event Contact
- Name:
- Pam Engelberts
- Phone:
- 0450271561
- Email:
- s4556136@student.uq.edu.au
- Org. Unit:
- Marine Science
Event Description
- Full Description:
- Hi everyone!
The Centre for Marine Science is pleased to invite you to a special seminar (and the last seminar of 2021) next Tuesday 23rd November at 4pm AEST. Please note the change from our regular time to 4pm, to accommodate different time zones.
The seminar will be held on Zoom. Please register in advance:
https://uqz.zoom.us/meeting/register/tZcpduuuqTIsE9Qee-kSPYKQkUo4HgvVYYRo
We will be joined by Dr. Benedikt Geier from the Max Planck Institute for Marine Microbiology in Bremen, Germany. Dr Geier’s recent work has developed innovative tools to unravel spatial metabolomics, advancing our understanding of host-symbiont interactions in marine invertebrates. We are excited to have him present his research on imaging anatomic structure and metabolic function in animal-microbe symbioses in situ.
You can find the abstract of the talk below.
We hope to see you on Zoom next Tuesday.
Cheers,
Pam Engelberts & Gretel Waugh
PhD students (ACE/SCMB)
Imaging anatomic structure and metabolic function in animal-microbe symbioses in situ
Dr. Benedikt Geier, Max-Planck-Institut für Marine Mikrobiologie
Organisms are a symphony of molecules, orchestrated through chemical reactions and performed in a three-dimensional (3D) architecture. In animal–microbe symbioses, small molecules, so called metabolites not only provide essential building blocks of cells and membranes, but also enable both partners to interact. Mass spectrometry imaging (MSI) lets us visualize how these metabolites are distributed in tissues where host cells and associated bacteria meet. Therefore, MSI provides a powerful approach to disentangle the metabolic fingerprints and interactions of microbes in animal tissues. However, the major challenge is to determine whether the location of a given metabolite corresponds to the location of the animal’s cells or the bacteria.
We developed approaches to combine MSI, microscopy and computed tomography, to tease apart the metabolic fingerprints of host animals and symbiotic bacteria living inside the animal tissues and cells. Focusing on an invertebrate animal–bacteria symbioses we investigated chemosynthetic mussels of the genus Bathymodiolus from deep-sea vents that depend on their microbial symbionts for nutrition.
By combining high-resolution (MALDI-)MSI with fluorescence in situ hybridization (FISH) to label the intracellular symbiotic bacteria, we could assign hundreds of metabolite distributions to either the host or its symbionts within a single measurement. Applying the combined MSI and FISH approach not only showed that the intracellular symbiont colonies were metabolically heterogeneous at the micrometer scale, but also revealed a group of metabolites linked to the interaction between mussel and symbionts.
With integrating MSI and FISH we wanted to provide a tool for microbiologists to tease apart metabolic fingerprints of bacteria – good and bad – in mixed communities and eukaryotic tissues.
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