Event Details

Date:
Monday, 02 September 2019 - Monday, 02 September 2019
Time:
11:00 am - 12:00 pm
Room:
Auditorium, room 701, QBI Building 79
UQ Location:
Queensland Brain Institute (St Lucia)
URL:
https://qbi.uq.edu.au/event/neuroscience-seminars
Event category(s):

Event Contact

Name:
Ms Charmaine Paiva
Phone:
66402
Email:
m.paiva@uq.edu.au
Org. Unit:
Queensland Brain Institute

Event Description

Full Description:
Seminar speaker : Professor Gordon Fishell, Professor of Neurobiology, Harvard Medical School, USA

Seminar title :
Making up your mind, the specification and integration of interneurons into the cortex

Abstract :
My talk will be focused on two complementary aspects of cortical interneuron development. Firstly, from a developmental genetics vantage we are examining the trajectories by which cortical interneurons are generated from their anlage, the three ganglionic eminences, the medial, lateral and caudal ganglionic eminences. Historically, this has involved fate mapping these progenitor zones (Wichterle et al., 2001; Nery et al., 2003, Butt et al., 2005, Miyoshi et al., 2007, 2010). More recently this work has been complemented by single cell RNA-seq analysis (Mayer et al., in preparation) demonstrating the underlying logic by which interneuron and projection neurons are specified during development.
Secondly, the laboratory has increasing intrigued by postnatal events by which cortical interneurons become integrated into brain circuits. Beginning with the recognition that modulation of activity can affect both the migration and morphological development of interneurons (De Marco et al., 2011), the laboratory has become interested in the connection between activity, gene expression (Demarco et al., 2015) and alternative splicing (Wamsley et al., 2018). I will discuss recent evidence indicating that the splice factors Nova1 and Nova2 direct synaptogenesis in response to activity mediated splicing.

Directions to UQ

Google Map:
Directions:
St Lucia Campus | Gatton campus.

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