QBI Neuroscience Seminar: 'All-optical closed-loop manipulation of neural circuits in vivo'

Event Details

Date:

Thursday, 23 May 2019 - Thursday, 23 May 2019

Time:

11:00 am - 12:00 pm

Room:

QBI Level 7 Auditorium

UQ Location:

Queensland Brain Institute (St Lucia)

URL:

http://www.qbi.uq.edu.au/neuroscience-seminars

Event category(s):

Full Description:: Professor Michael Hausser FRS
Wolfson Institute for Biomedical Research
University College London, UK

Title: 'All-optical closed-loop manipulation of neural circuits in vivo'

Abstract: Understanding the causal relationship between activity patterns in neural circuits and behavior will require the ability to perform rapid and targeted interventions in ongoing neuronal activity. I will describe a novel closed-loop all-optical strategy for dynamically controlling neuronal activity patterns in awake mice. This involves rapid tailoring and delivery of two-photon optogenetic stimulation based on readout of activity using simultaneous two-photon imaging of the same neural population. This closed-loop feedback control can be used to clamp spike rates at pre-defined levels, boost weak sensory-evoked responses, and activate network ensembles based on detected activity. By optically 'yoking together' neighboring neurons, it can also be used to induce long-term changes in network dynamics. This approach thus allows the rate and timing of activity patterns in neural circuits to be flexibly manipulated ‘on the fly’ during behavior.