IMB Seminar Series - Associate Professor Allison Pettit - Bone and marrow resident macrophages regulate both hematopoietic and skeletal health and regeneration

Event Details

Date:

Friday, 29 June 2018

Time:

12:30 pm - 1:30 pm

Room:

QBP Auditorium

UQ Location:

Queensland Bioscience Precinct (St Lucia)

URL:

https://imb.uq.edu.au/event/8822/imb-friday-seminar-series

Event category(s):

Full Description:: Bone and marrow resident macrophages regulate both hematopoietic and skeletal health and regeneration

Bone and bone marrow (BM) are interdependent organs with reciprocal regulatory functions throughout life. Bone and BM contain multiple functionally distinct resident macrophage subsets, including haematopoietic stem cell (HSC) niche macrophages and osteal tissue macrophages (osteomacs). Using multiple in vivo and ex vivo strategies we have demonstrated that osteomacs and HSC niche macrophages play an integral roles in regeneration of bone and bone marrow after injury. Consequently macropahges represent an attractive cellular target to promote bone and bone marrow repair after acute injury or as a consequence of age-mediated functional decline.