IMB Seminar Series - Professor Raymond S Norton - 'Autoimmune diseases and diabetes - animal venom peptides as a basis for novel therapeutics'
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- Autoimmune diseases and diabetes - animal venom peptides as a basis for novel therapeutics
Animal venoms are a rich source of peptides that are potent and often exquisitely selective probes of the structure and function of ion channels and receptors. I will describe our studies on peptides from sea anemones and scorpions that are potent blockers of Kv1.3 channels and show considerable potential as therapeutics for autoimmune diseases.
As another example, we identified insulins in the venom of a fish-hunting cone snail. We determined the structure of one of these insulins and modelled its interaction with the insulin receptor. Con-Ins G1 has the potential to guide the development of novel rapidly-acting human insulin analogues.
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