Modulating the trajectory of brain recovery after stroke from bench to bedside
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- Dr Lin Kooi Ong
University of Newcastle and Hunter Medical Research Institute
New South Wales, Australia
Stroke patients often find it difficult to do cognitive tasks, such as learning and recall memories. Our research team is undertaking controlled laboratory experiment to investigate the factors that influence brain recovery after stroke. Here, we found that stroke triggers a neurodegenerative condition, leading to activation of diverse cell types involved in survival and cell death mechanisms.
We have published compelling pre-clinical evidence that certain environmental experiences, such as chronic stress, greatly obstruct the recovery process. Moving forward in clinical population, we are establishing a stress monitoring program for stroke patients which involves the measurement of biological stress parameters as well as psychometric assessments. Excitingly, we are working on a number of therapeutic opportunities for brain recovery after stroke. Using experimental stroke model, we found that growth hormone treatment stimulates cognitive recovery and brain plasticity.
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