QBI Neuroscience Seminar: Role of EphA4 in regulating adult hippocampal neurogenesis and motor neuron disease

Event Details

Date:

Wednesday, 22 February 2017

Time:

11:00 am - 12:00 pm

Room:

QBI Level 7 Auditorium

UQ Location:

Queensland Brain Institute (St Lucia)

URL:

http://www.qbi.uq.edu.au/neuroscience-seminars

Event category(s):

Full Description:: Jing Zhao
Queensland Brain Institute, University of Queensland

Title: Role of EphA4 in regulating adult hippocampal neurogenesis and motor neuron disease

Abstract: The ephrin receptor, EphA4, is member of a large family of receptor tyrosine kinases, shown to play a role in the development and function of the nervous system. I will present new evidence about the novel role EphA4 plays in regulating neurogenesis in the adult hippocampus and the mechanism underlying its regulation. Recently, EphA4 has been also identified as a disease regulator in motor neuron disease (MND), which is characterised by the progressive degeneration of motor neurons. I have identified novel isoforms of EphA4 and will discuss their expression and putative function in the pathogenesis of MND.