Dr Georgia Kafer, Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University 5-Hydroxymethylcytosine marks sites of DNA damage and promotes genome stability
Event Details
- Date:
- Friday, 02 September 2016
- Time:
- 3:00 pm - 4:00 pm
- Room:
- QBI auditorium, Level 7 (#79)
- UQ Location:
- Queensland Brain Institute (St Lucia)
- URL:
- http://www.uq.edu.au/sbms/sbms-seminars-2016
- Event category(s):
Event Contact
- Name:
- Ms Avril Johnston-Craig
- Phone:
- 336 51536
- Email:
- a.johnstoncraig@uq.edu.au
- Org. Unit:
- Biomedical Sciences
Event Description
- Full Description:
- In 2011, after completing a PhD on dynamic changes in histone variants during preimplantation development at the University of Queensland (UQ), Dr Kafer was appointed as an associate lecturer in cell and developmental biology at the School of Biomedical Sciences (UQ).
In 2012 Dr Kafer won a competitive JSPS Postdoctoral Fellowship to undertake research at The Institute for CellMaterial Sciences (iCeMS) in Kyoto Japan. Dr Kafer worked under the mentorship of Prof. Norio Nakatsuji and was based in the laboratory of A/Prof. Peter Carlton. During this time she developed skills relating to the culture and differentiation of human embryonic stem cells and the use of high and super resolution microscopes. Here she made some interesting discoveries relating to the dynamics of modified histones at early stages of differentiation that specifically correlate to a loss of pluripotency.
In 2014, at the conclusion of her fellowship, Dr Kafer began her second postdoc working in the lab of A/Prof. Peter Carlton where she began to use Cas9/CRISPR technology to investigate DNA methylation. Dr Kafer is still based there and has two ongoing research projects. The first investigate the role of DNA methylation and hydroxymethylation in DNA damage pathways of cancer cells and stem cells. The second project is in collaboration with A/Prof. KenIchiro Kamei and involves growing trophoblast like cells differentiated from human embryonic stem cells on 3D PDMS substrates in an attempt to recapitulate placental villi in vitro to generate an ethical model for human placental development and function.
Directions to UQ
- Google Map:
-
- Directions:
- St Lucia Campus | Gatton campus.
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