QBI Neuroscience Seminar: Measurements of dopamine and serotonin release with sub-second temporal resolution in humans: Implications for understanding mechanisms underlying human decision-making, cognition, and mental illness
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- Dr Kenneth T Kishida, Human Neuroimaging Laboratory & Computational Psychiatry Unit, Virginia Tech Carilion Research Institute, Roanoke, VA24016, USA
Title: Measurements of dopamine and serotonin release with sub-second temporal resolution in humans: Implications for understanding mechanisms underlying human decision-making, cognition, and mental illness
Abstract:
Dopamine and serotonin are critical neuromodulators whose actions underlie learning, decision-making, and behavioral control. Degeneration of dopamine neurons underlies the progression of Parkinson’s disease; and disruptions in serotonin and dopamine signaling are believed to underlie many psychiatric conditions. We have recently published the world’s first sub-second measurements of dopamine release in humans. These measurements were made while participants (patients undergoing deep-brain stimulation implantation surgery for Parkinson’s disease) played a monetarily incentivized decision-making game. I will discuss our group’s recent technological achievements, which now (1) extend this technology to simultaneously measure dopamine and serotonin during active decision-making and (2) begin to provide real-time data about the roles these signals play during adaptive behavior in humans.
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