QBI Neuroscience Seminar: Restless resting state: neural basis and application in rodent models
Event Details
- Date:
- Wednesday, 10 February 2016 - Wednesday, 10 February 2016
- Time:
- 12:00 pm - 1:00 pm
- Room:
- QBI Level 7 Auditorium
- UQ Location:
- Queensland Brain Institute (St Lucia)
- URL:
- http://www.qbi.uq.edu.au/neuroscience-seminars
- Event category(s):
Event Contact
- Name:
- Ms Deirdre Wilson
- Phone:
- 3346 6300
- Email:
- d.wilson5@uq.edu.au
- Org. Unit:
- Queensland Brain Institute
Event Description
- Full Description:
- A/Professor Kai-Hsiang Chuang, Queensland Brain Institute, University of Queensland
Title: Restless resting state: neural basis and application in rodent models
Abstract:
Synchronous neural oscillation across the brain provides information on the functional connectivity of the brain. In the past decade, spontaneous low-frequency oscillation of the resting brain shows networks that match functional organization of the brain has been observed, especially using resting-state functional MRI (rsMRI). Functional network plasticity and its deficit in development, mental processes, aging and diseases have been observed. While many studies have tried to correlate rsMRI with electrophysiology and structural connectivity, its underlying neurophysiological and neuroarchitectural bases are still not clear.
To understand the neural basis of rsMRI and to determine whether it can be a translatable biomarker for biomedical research, we established the technique in anesthetized rodent brain. Using drugs that target to specific neural receptors, we observed that functional connectivity strength is regional receptor density, drug dosage and time dependent. Correlation with electrophysiology further confirms the change was not due to vascular response. The technique was applied to measure neural plasticity after learning, and to evaluate treatment effects in transgenic mouse models of neurodegenerative diseases. These understanding will facilitate our interpretation of the rsMRI signals and the translation from animal models to human.
Directions to UQ
- Google Map:
-
- Directions:
- St Lucia Campus | Gatton campus.
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