2015 Toshiya Yamada Memorial Lecture: Role of Tau and amyloid in Alzheimers disease - from basic mechanisms to therapeutic interventions
Event Details
- Date:
- Wednesday, 25 November 2015
- Time:
- 2:00 pm - 3:00 pm
- Room:
- QBP Auditroium, Building 80
- UQ Location:
- Queensland Bioscience Precinct (St Lucia)
- URL:
- http://www.imb.uq.edu.au/2015-toshiya-yamada-memorial-lecture
- Event category(s):
Event Contact
- Name:
- Ms Sue Allen
- Phone:
- 3346 2112
- Email:
- s.allen@imb.uq.edu.au
- Org. Unit:
- Institute for Molecular Bioscience
Event Description
- Full Description:
- In Alzheimer’s disease (AD), genetic and biochemical data have established a crucial role for the amyloid-β (Aβ) peptide that forms extracellular deposits known as amyloid plaques. A second key player in AD is the microtubule-associated protein Tau that forms intracellular deposits referred to as neurofibrillary tangles. My laboratory has contributed to an understanding at the molecular level of how these two molecules, both separately and synergistically, impair neuronal functions. At present AD cannot be cured. From a therapeutic point of view, both Tau and Aβ have been recognized as attractive targets interventions, although Tau is lagging behind Aβ therapies. In my lecture, I will talk about our work on understanding tau and Aβ toxicity; I will also present novel approaches of reducing Aβ and tau pathology in mice, by combining therapeutic agents with a novel ultrasound-based delivery method.
Professor Jürgen Götz is the Foundation Chair of Dementia Research and Director of the Clem Jones Centre for Ageing Dementia Research (CJCADR) at the Queensland Brain Institute (QBI), The University of Queensland. Götz studied biochemistry at the University of Basel, and earned his PhD in immunology in the laboratory of Nobel Laureate Georges Köhler at the Max-Planck-Institute in Freiburg, Germany. After postdoctoral work at UCSF and the Preclinical Research Division at Novartis Ltd in Basel, he established his reputation in the Alzheimer’s field as a research group leader at the University of Zürich (1994-2005). In 2005, he was recruited as Chair of Molecular Biology to the University of Sydney, until taking up his new position at the University of Queensland in 2012. A major focus of the laboratory is the generation and analysis of transgenic animal models to gain a better mechanistic understanding of Alzheimer’s disease and related dementias. He and his team use these animal models to develop therapeutic interventions targeting two key molecules in disease, tau and amyloid-beta. Professor Götz has authored more than 140 articles in leading journals in the field.
Directions to UQ
- Google Map:
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- Directions:
- St Lucia Campus | Gatton campus.
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