QBI Seminar: Mobile RNA and trans-generational epigenetic inheritance - mechanisms, functions, and prevalence
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- Professor Craig Hunter
Department of Molecular and Cellular Biology, Harvard University, Cambridge, USA
Title: Mobile RNA and trans-generational epigenetic inheritance: Mechanisms, functions, and prevalence
Abstract:
The discovery of RNA interference (RNAi) in C. elegans was accompanied by the observation that the RNA-induced silencing signals are mobile, spreading between cells to knockdown gene expression throughout the animal and in its progeny. Dr. Hunter was fascinated by this observation and through classic forward genetics identified and characterized the responsible RNA transport proteins and then determined their mechanisms of action. His current interests include pursuing the function of mobile RNAs in animals, which has led to investigations of antiviral immunity, multi-generational inheritance of acquired traits, and transport of endogenous somatic RNA to germ cells
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